International name: Fluconazole

Dosage band and prescription: 100 mg capsules for oral intake

Formula:

Active substance: Fluconazole

Additives: lactose monohydrate, colloidal silicium dioxide, magnesium stearate, rice meal, sodium lauryl sulfate

Pharmacotheraputical group:

Flukas belongs to the antifungal group of preparations

Indication and usage:

Medical treatment can be started before getting the results of cultural diagnostics and other laboratory tests, but after getting the results of mycological examination the scheme of treatment has to be appropriately adjusted.

Fluconazole is indicated for the treatment and prevention of the following illnesses caused by pathogenic fungus:

• Cryptococcosis, including cryptococcal meningitis and other localizations of this infection (lungs, skin and other).
• General candidiasis, including candidemia, disseminated candidiasis and other forms of invasive candidal infections, including candidal damage of peritoneum, endocardium, eyes, respiratory and urinary tract, and other organs.
• Candidiasis of mucous coat, including mucous coat damage of oral cavity, pharynx, esophagus; noninvasive bronchopulmonary candidiasis, candiduria, skin moniliasis, atrophic oropharyngeal candidiasis, caused by wearing dental prosthesis.
• Genital candidiasis, including vaginal candidiasis (acute or chronic recurrent).
• Prophylaxis of mycotic lesion in patients with malignant growths inclined to such infections as the result of cytostatic treatment and radiotherapy.
• Dermatomycosis, including foot mycosis, inguinal region mycosis, chromophytosis, onychomycosis, skin moniliasis.
• Systemic endemic mycosis, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with average immunity.

Contraindication:

Preparation is contraindicated in patients who have shown hypersensitivity to

fluconazole or to those, similar in composition to azoles, to other constituents of preparation.

It is not recommended to prescribe the preparation during pregnancy or lactation period.

Overdosage:

Single application of excessive dosage of fluconazole may lead to breakdown. See Your doctor immediately or resort to the nearest medical institution.

Take capsules with water.

It is recommended to take capsules at one and the same time of the day.

Preparation can be taken both during mealtimes and during intervals between food intake.

Drug route and dosage:

Preparation should be taken according to doctor’s prescription in order to avoid complications.

Daily doze of fluconazole depends on the type and severity of fungal infections.

Treatment, as the rule, involves multiple intake of the preparation up to the full disappearance of clinical and laboratory symptoms.

In case of early interruption of treatment relapse is possible.

ADULTS:

• Oropharyngeal candidiasis- 50-100mg once daily during 7–14 days and more.
• Oropharyngeal infections caused by wearing dental prosthesis- 50mg once daily during 14 days (on condition of prosthesis disinfection).
• Candidal infections of esophagus, noninvasive lung infections, urinary tract infections, and conditions caused by mucocutaneous candidiasis- 50-100mg once daily during 14–30 days.
• Prevention of oropharyngeal candidiasis relapse in patients with AIDS- 150mg once a week.
• Treatment of genital candidiasis- 150mg once.
• Treatment of women with relapse of vaginal candidiasis (3 or more times a year) — 150mg once a month during 4–12 months and more if required.
• Fungal skin infections- 50mg once daily and 150mg once a week during 2–4 weeks.
• Feet dermatomycosis’s required length of treatment may come up to 6 weeks.
• Chromophytosis- 300mg once a week during 2 weeks. Some patients might require third dose of 300 mg a week, while 300-400mg of Fluconazole once are enough for other patients. Another scheme of treatment — 50mg daily during 2–4 weeks.
• Onychomycosis- 150mg once a week, usually during 3–6 months (hands) and 6–12 months (feet).
• Candidiasis of internal organs — 400mg (first day), then 200-400mg once daily. In cases of candidal infections that are life-threatening, the dose can be increased up to 800mg daily.
• Prevention of candidal infections relapse -50- 4mg once daily during the risky period of
• development of infection.
• Cryptococcal infections of internal organs- 400mg (first day), then 200-400mg once daily. In cases of cryptococcal infections that are life-threatening, the dose can be increased up to 800mg once daily.
• For suppression of relapse of cryptococcal meningitis in patients with AIDS- 200mg daily during uncertain length of time.
• Coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis- 200-400mg once daily during 2 оr more years.

CHILDREN at the age of 4-15years:

• Oropharyngeal candidal infections- 3mg/kg once daily (first day), further 6mg/kg daily.
• Candidal or cryptococcal infections of internal organs- 6–12 mg/kg once daily.
• Prevention of fungal infections during the risky period of their development- 3–12 mg/kg daily.

AGE 3–4 weeks- same dose is taken in 48 hours.

AGE 2 weeks- same dose is taken in 72 hours.

ELDERLY PEOPLE

If case of absence of kidney diseases, the preparation is prescribed in the same dose as for adults.

PATIENTS WITH KIDNEY DISEASES:

Doctor can change the dose according to the function of kidneys. Doctors sometimes prescribe the preparation in other doses.

If You missed the intake of preparation, do not worry and take another dose at the usual time.

Side effect:

Usually Flukas is tolerated well by patients. There are rarely dyspeptic effects, headache.

Form of issue:

Capsules. Fluconazole 100mg.7 capsules in blister.

Conditions of delivery at chemistry stores:

Delivered according to prescription.

Terms of storage:

Should be stored under temperature -not above 25˚ С and kept out of reach of children.

Expiry period:

Do not take the preparation after the expiry date printed on the package.